Hedonic and Behavioral Deficits Associated with Apathy in Parkinson’s Disease: Potential Treatment Implications
Identifieur interne : 000968 ( Main/Exploration ); précédent : 000967; suivant : 000969Hedonic and Behavioral Deficits Associated with Apathy in Parkinson’s Disease: Potential Treatment Implications
Auteurs : Lizabeth L. Jordan [États-Unis] ; Laura B. Zahodne [États-Unis] ; Michael S. Okun [États-Unis] ; Dawn Bowers [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Behavioral Symptoms.
- physiology : Apathy.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Psychiatric Status Rating Scales, Regression Analysis.
Abstract
Many individuals with Parkinson’s disease (PD) experience apathy independent of depression. In this study we examined hedonic and behavioral deficits related to apathy in 50 PD patients and 42 healthy older adults who completed standardized measures. Regression analyses revealed that apathy was associated with anticipatory, but not consummatory, anhedonia and reduced goal-directed behavior, independent of PD diagnosis, age, education and depressive symptoms. These findings suggest that apathy is characterized by deficits in anticipatory pleasure and behavioral drive rather than consummatory pleasure or reward responsiveness. Therefore, PD patients with apathy would likely benefit from psychotherapeutic treatment that encourages structured, goal-directed plans for pleasurable events and stimulation which provide adaptive hedonic effects. In addition, given the proposed shared mechanism of dopamine depletion within the ventral striatum in apathy and anticipatory anhedonia, future trials of dopamine-eliciting activities (e.g. exercise and other non-pharmacologic methods) appear warranted to improve these symptoms in PD.
Url:
DOI: 10.1002/mds.25496
PubMed: 23712560
PubMed Central: 3760996
Affiliations:
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Jordan</name><affiliation><nlm:aff id="A1">University of Florida, Center for Movement Disorders and Neurorestoration</nlm:aff><wicri:noCountry code="subfield">Center for Movement Disorders and Neurorestoration</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">University of Florida, Department of Clinical and Health Psychology, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, Department of Clinical and Health Psychology, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. 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Jordan</name><affiliation><nlm:aff id="A1">University of Florida, Center for Movement Disorders and Neurorestoration</nlm:aff><wicri:noCountry code="subfield">Center for Movement Disorders and Neurorestoration</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">University of Florida, Department of Clinical and Health Psychology, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, Department of Clinical and Health Psychology, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name><affiliation><nlm:aff id="A1">University of Florida, Center for Movement Disorders and Neurorestoration</nlm:aff><wicri:noCountry code="subfield">Center for Movement Disorders and Neurorestoration</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Columbia University College of Physicians & Surgeons, Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and The Aging Brain, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Columbia University College of Physicians & Surgeons, Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and The Aging Brain, New York</wicri:cityArea></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation><nlm:aff id="A1">University of Florida, Center for Movement Disorders and Neurorestoration</nlm:aff><wicri:noCountry code="subfield">Center for Movement Disorders and Neurorestoration</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">University of Florida, Department of Neurology, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, Department of Neurology, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">University of Florida, Department of Neurosurgery, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, Department of Neurosurgery, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation><nlm:aff id="A1">University of Florida, Center for Movement Disorders and Neurorestoration</nlm:aff><wicri:noCountry code="subfield">Center for Movement Disorders and Neurorestoration</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">University of Florida, Department of Clinical and Health Psychology, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, Department of Clinical and Health Psychology, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">University of Florida, Department of Neurology, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Florida, Department of Neurology, Gainesville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apathy (physiology)</term><term>Behavioral Symptoms (etiology)</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Psychiatric Status Rating Scales</term><term>Regression Analysis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Behavioral Symptoms</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apathy</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term><term>Regression Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Many individuals with Parkinson’s disease (PD) experience apathy independent of depression. In this study we examined hedonic and behavioral deficits related to apathy in 50 PD patients and 42 healthy older adults who completed standardized measures. Regression analyses revealed that apathy was associated with anticipatory, but not consummatory, anhedonia and reduced goal-directed behavior, independent of PD diagnosis, age, education and depressive symptoms. These findings suggest that apathy is characterized by deficits in anticipatory pleasure and behavioral drive rather than consummatory pleasure or reward responsiveness. Therefore, PD patients with apathy would likely benefit from psychotherapeutic treatment that encourages structured, goal-directed plans for pleasurable events and stimulation which provide adaptive hedonic effects. In addition, given the proposed shared mechanism of dopamine depletion within the ventral striatum in apathy and anticipatory anhedonia, future trials of dopamine-eliciting activities (e.g. exercise and other non-pharmacologic methods) appear warranted to improve these symptoms in PD.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Jordan, Lizabeth L" sort="Jordan, Lizabeth L" uniqKey="Jordan L" first="Lizabeth L." last="Jordan">Lizabeth L. Jordan</name></region><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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